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Nerve growth factor binds to TrkA receptors on axon terminals, generating a survival signal that is propagated along the axon to the cell body of the neuron. In their Perspective, Miller and Kaplan discuss exciting new findings (MacInnis and Campenot) demonstrating that nerve growth factor does not have to be internalized with its receptor for the survival signal to be retrogradely transported along the axon to the neuronal cell body.
The authors are at the Centre for Neuronal Survival and Brain Tumor Research Centre, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A 2B4, Canada. E-mail: freda.miller@mcgill.ca, david.kaplan@mcgill.ca
One at a time, live tracking of NGF axonal transport using quantum dots.
B. Cui, C. Wu, L. Chen, A. Ramirez, E. L. Bearer, W.-P. Li, W. C. Mobley, and S. Chu (2007)
PNAS
104, 13666-13671
|Abstract »|Full Text »|PDF »
Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase.
A. Woronowicz, S. R. Amith, K. De Vusser, W. Laroy, R. Contreras, S. Basta, and M. R. Szewczuk (2007)
Glycobiology
17, 10-24
|Abstract »|Full Text »|PDF »
Retrograde Gbb signaling through the Bmp type 2 receptor Wishful Thinking regulates systemic FMRFa expression in Drosophila.
G. Marques, T. E. Haerry, M. L. Crotty, M. Xue, B. Zhang, and M. B. O'Connor (2003)
Development
130, 5457-5470
|Abstract »|Full Text »|PDF »
