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DEVELOPMENT: Epithelial Cell Differentiation--a Mather of Choice
Gijs R. van den Brink, Pascal de Santa Barbara, Drucilla J. Roberts
The epithelium of the gut is composed of four different cell types that differentiate from a common progenitor stem cell pool in the crypts. But what are the signals that influence progenitor cells to adopt one of four possible cell fates? In a Perspective, van den Brink et al. discuss new findings (Yang et al.) that identify the transcription factor, Math1, as an important mediator of cell fate choice by gut epithelial progenitor cells.
G. R. van den Brink is at the Academic Medical Center, Department of Experimental Internal Medicine in the Netherlands. D. J. Roberts and P. de Santa Barbara are in the Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA. E-mail: djroberts{at}partners.org
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In Science Magazine
REPORTS
Qi Yang, Nessan A. Bermingham, Milton J. Finegold, and Huda Y. Zoghbi (7 December 2001) Science294 (5549), 2155.
[DOI: 10.1126/science.1065718] |Abstract »|Full Text »|PDF »|Supplemental Data »
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