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Science 7 December 2001:
Vol. 294. no. 5549, pp. 2111 - 2113
DOI: 10.1126/science.1067628
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Perspectives

SIGNAL TRANSDUCTION:
RIPping Tyrosine Kinase Receptors Apart

Carl-Henrik Heldin and Johan Ericsson

A ligand binding to its transmembrane receptor can activate several different signaling pathways that indirectly switch on the transcription of target genes in the nucleus. As Heldin and Ericsson explain in their Perspective, new findings reveal that some receptors such as ErbB-4 can also take a more direct approach to activating gene transcription (Ni et al.). Once bound to ligand, ErbB-4 is proteolytically cleaved twice. First the ectodomain is released, then intramembrane cleavage releases a cytoplasmic fragment, which moves to the nucleus where it may affect gene expression.

The authors are at the Ludwig Institute for Cancer Research, Box 595, Biomedical Center, SE-751 24 Uppsala, Sweden.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)