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Science 2 November 2001:
Vol. 294. no. 5544, pp. 1015 - 1016
DOI: 10.1126/science.1066728

Perspectives

CELL BIOLOGY:
Fusion Without SNAREs?

Suzie J. Scales, Michael F. A. Finley, Richard H. Scheller

Highly orchestrated molecular rearrangements are required for two membranes to fuse, as happens, for example, during neurotransmitter release into the synapse. In an elegant Perspective, Scales et al. discuss two studies (Schoch et al., Wang et al.) that shed new light on the protein interactions involved in membrane fusion.


S. J. Scales and R. H. Scheller are at Genentech Inc., South San Francisco, CA 94080, USA. M. F. A. Finley is in the Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305, USA. E-mail: sscales{at}gene.com

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin and Hypertonicity Recruit GLUT4 to the Plasma Membrane of Muscle Cells by Using N-Ethylmaleimide-sensitive Factor-dependent SNARE Mechanisms but Different v-SNAREs: Role of TI-VAMP.
V. K. Randhawa, F. S.L. Thong, D. Y. Lim, D. Li, R. R. Garg, R. Rudge, T. Galli, A. Rudich, and A. Klip (2004)
Mol. Biol. Cell 15, 5565-5573
   Abstract »    Full Text »    PDF »
Initiation and Dynamics of Hemifusion in Lipid Bilayers.
G. Hed and S. A. Safran (2003)
Biophys. J. 85, 381-389
   Abstract »    Full Text »    PDF »
Regulated secretion: SNARE density, vesicle fusion and calcium dependence.
J. R. Coorssen, P. S. Blank, F. Albertorio, L. Bezrukov, I. Kolosova, X. Chen, P. S. Backlund Jr, and J. Zimmerberg (2003)
J. Cell Sci. 116, 2087-2097
   Abstract »    Full Text »    PDF »
High Resolution Structure, Stability, and Synaptotagmin Binding of a Truncated Neuronal SNARE Complex.
J. A. Ernst and A. T. Brunger (2003)
J. Biol. Chem. 278, 8630-8636
   Abstract »    Full Text »    PDF »
Analysis of Sec22p in Endoplasmic Reticulum/Golgi Transport Reveals Cellular Redundancy in SNARE Protein Function.
Y. Liu and C. Barlowe (2002)
Mol. Biol. Cell 13, 3314-3324
   Abstract »    Full Text »    PDF »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)