Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Suzie J. Scales, Michael F. A. Finley, Richard H. Scheller
Highly orchestrated molecular rearrangements are required for two membranes to fuse, as happens, for example, during neurotransmitter release into the synapse. In an elegant Perspective, Scales et al. discuss two studies (Schoch et al., Wang et al.) that shed new light on the protein interactions involved in membrane fusion.
S. J. Scales and R. H. Scheller are at Genentech Inc., South San Francisco, CA 94080, USA. M. F. A. Finley is in the Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305, USA. E-mail: sscales{at}gene.com
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Chih-Tien Wang, Ruslan Grishanin, Cynthia A. Earles, Payne Y. Chang, Thomas F. J. Martin, Edwin R. Chapman, and Meyer B. Jackson (2 November 2001) Science294 (5544), 1111.
[DOI: 10.1126/science.1064002] |Abstract »|Full Text »|PDF »|Supplemental Data »
REPORTS
Susanne Schoch, Ferenc Deák, Andreas Königstorfer, Marina Mozhayeva, Yildirim Sara, Thomas C. Südhof, and Ege T. Kavalali (2 November 2001) Science294 (5544), 1117.
[DOI: 10.1126/science.1064335] |Abstract »|Full Text »|PDF »|Supplemental Data »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin and Hypertonicity Recruit GLUT4 to the Plasma Membrane of Muscle Cells by Using N-Ethylmaleimide-sensitive Factor-dependent SNARE Mechanisms but Different v-SNAREs: Role of TI-VAMP.
V. K. Randhawa, F. S.L. Thong, D. Y. Lim, D. Li, R. R. Garg, R. Rudge, T. Galli, A. Rudich, and A. Klip (2004)
Mol. Biol. Cell
15, 5565-5573
|Abstract »|Full Text »|PDF »
Initiation and Dynamics of Hemifusion in Lipid Bilayers.
Regulated secretion: SNARE density, vesicle fusion and calcium dependence.
J. R. Coorssen, P. S. Blank, F. Albertorio, L. Bezrukov, I. Kolosova, X. Chen, P. S. Backlund Jr, and J. Zimmerberg (2003)
J. Cell Sci.
116, 2087-2097
|Abstract »|Full Text »|PDF »
High Resolution Structure, Stability, and Synaptotagmin Binding of a Truncated Neuronal SNARE Complex.