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Science 2 November 2001:
Vol. 294. no. 5544, pp. 1011 - 1012
DOI: 10.1126/science.294.5544.1011
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

NEUROBIOLOGY:
Enhanced: Neurocreationism--Making New Cortical Maps

Pasko Rakic

In developing mammals, how does the cerebral cortex become compartmentalized into different regions responsible for functions as diverse as motor control and sensory perception? Rakic explains in his Perspective that morphogenetic molecules such as FGF8 (Fukuchi-Shimogori and Grove) form gradients that specify the boundaries of different cortical regions, which are then further modified by input from the thalamus and other cerebral structures.

The author is in the Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA. E-mail: pasko.rakic{at}yale.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)