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Science 28 September 2001:
Vol. 293. no. 5539, pp. 2404 - 2405
DOI: 10.1126/science.1065677
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Perspectives

CELL BIOLOGY:
Life Without Caveolae

Robert G. Parton

Many mammalian cells have indentations in the plasma membrane called caveolae, but exactly what these flask-shaped pits do remains unclear. In a Perspective, Parton discusses the characteristics of caveolin-1-deficient mice that lack caveolae (Drab et al.). The mice are fertile and seem healthy but show cardiovascular defects, suggesting that caveolae may be important in nitric oxide signaling and cellular proliferation.

The author is at the Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis, and School of Biomedical Sciences, University of Queensland, Queensland 4072, Australia. E-mail: r.parton{at}imb.uq.edu.au

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