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Science 24 August 2001:
Vol. 293. no. 5534, pp. 1446 - 1447
DOI: 10.1126/science.1064684
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

BIOMEDICINE:
Enhanced: Tauists and baptists United--Well Almost!

Virginia M.-Y. Lee

Controversy still rages over which of the two hallmark pathologies of Alzheimer's disease (AD), amyloid plaques and tau tangles, is the primary cause of neurodegeneration in the brain. As many suspected and as Lee points out in her Perspective, the two pathologies are not separate processes. New work (Lewis et al., Götz et al.) in transgenic mice shows that amyloid-b deposits influence the formation of tau tangles in areas of the brain known to be affected in AD.

The author is at the Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA. E-mail: vmylee{at}mail.med.upenn.edu

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Journal Watch (General) 2001, 8
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