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Regulating the expression of target genes in response to different conditions is one of the most daunting tasks facing the cell. In a Perspective, Struhl describes the intricate steps involved in assembly of a precise transcriptional on-off switch called the enhanceosome, which regulates the transcription of the interferon-b gene in response to viral infection (Munshi et al.).
The author is in the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. E-mail: kevin{at}hms.harvard.edu
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In Science Magazine
REPORTS
Nikhil Munshi, Theodora Agalioti, Stavros Lomvardas, Menie Merika, Guoying Chen, and Dimitris Thanos (10 August 2001) Science293 (5532), 1133.
[DOI: 10.1126/science.293.5532.1133] |Abstract »|Full Text »|PDF »|Supplemental Data »
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