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It has been suspected that G6PD deficiency is widespread among humans because it confers a selective advantage. In a Perspective, Luzzatto and Notaro discuss findings from a molecular analysis of G6PD gene variants (Tishkoff et al.), which support the notion that G6PD deficiency has been selected for because it protects against infection with Plasmodium falciparum, the parasite that causes a fatal form of malaria.
The authors are at the National Institute for Cancer Research, Genova, Italy. E-mail: luzzatto{at}hp380.ist.unige.it
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In Science Magazine
RESEARCH ARTICLES
Sarah A. Tishkoff, Robert Varkonyi, Nelie Cahinhinan, Salem Abbes, George Argyropoulos, Giovanni Destro-Bisol, Anthi Drousiotou, Bruce Dangerfield, Gerard Lefranc, Jacques Loiselet, Anna Piro, Mark Stoneking, Antonio Tagarelli, Giuseppe Tagarelli, Elias H. Touma, Scott M. Williams, and Andrew G. Clark (20 July 2001) Science293 (5529), 455.
[DOI: 10.1126/science.1061573] |Abstract »|Full Text »|PDF »|Supplemental Data »
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