Bent Out of Shape

doi:10.1126/science.291.5512.2343

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Science 23 March 2001:
Vol. 291. no. 5512, p. 2343
DOI: 10.1126/science.291.5512.2343

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Bent Out of Shape

Michael Balter

LONDON--When it was first proposed in the early 1980s, the notion that aberrant proteins called prions can replicate without DNA or RNA and cause infectious diseases was biological heresy of the first order. Now, John Collinge is pushing the controversy a step farther, contending that the differences between prion types is in large part determined by how many carbohydrate molecules bind to a protein. This claim has helped make Collinge one of the prion world's most high-profile scientists.

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INTRODUCTION TO SPECIAL ISSUE Cinderella's Coach Is Ready: Stella Hurtley, Robert Service, and Phil Szuromi (23 March 2001)
Science 291 (5512), 2337. [DOI: 10.1126/science.291.5512.2337]
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NEWS Searching for Medicine's Sweet Spot: Joseph Alper (23 March 2001)
Science 291 (5512), 2338. [DOI: 10.1126/science.291.5512.2338]
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NEWS Saving Lives With Sugar: Joseph Alper (23 March 2001)
Science 291 (5512), 2339. [DOI: 10.1126/science.291.5512.2339]
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NEWS Sugar Separates Humans From Apes: Joseph Alper (23 March 2001)
Science 291 (5512), 2340a. [DOI: 10.1126/science.291.5512.2340a]
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NEWS After the Fall: Robert F. Service (23 March 2001)
Science 291 (5512), 2340b. [DOI: 10.1126/science.291.5512.2340b]
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NEWS The Best of Both Worlds?: Robert F. Service (23 March 2001)
Science 291 (5512), 2342. [DOI: 10.1126/science.291.5512.2342]
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REVIEW Toward Automated Synthesis of Oligosaccharides and Glycoproteins: Pamela Sears and Chi-Huey Wong (23 March 2001)
Science 291 (5512), 2344. [DOI: 10.1126/science.1058899]
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REVIEW Glycoprotein Structure Determination by Mass Spectrometry: Anne Dell and Howard R. Morris (23 March 2001)
Science 291 (5512), 2351. [DOI: 10.1126/science.1058890]
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REVIEW Chemical Glycobiology: Carolyn R. Bertozzi and Laura L. Kiessling (23 March 2001)
Science 291 (5512), 2357. [DOI: 10.1126/science.1059820]
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REVIEW Intracellular Functions of N-Linked Glycans: Ari Helenius and Markus Aebi (23 March 2001)
Science 291 (5512), 2364. [DOI: 10.1126/science.291.5512.2364]
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REVIEW Glycosylation and the Immune System: Pauline M. Rudd, Tim Elliott, Peter Cresswell, Ian A. Wilson, and Raymond A. Dwek (23 March 2001)
Science 291 (5512), 2370. [DOI: 10.1126/science.291.5512.2370]
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VIEWPOINT Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc: Lance Wells, Keith Vosseller, and Gerald W. Hart (23 March 2001)
Science 291 (5512), 2376. [DOI: 10.1126/science.1058714]
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Bent Out of Shape

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