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Science 10 November 2000:
Vol. 290. no. 5494, pp. 1108 - 1109
DOI: 10.1126/science.290.5494.1108
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Perspectives

MOLECULAR BIOLOGY:
Unwinding RNA Silencing

David C. Baulcombe

Eukaryotic cells have developed an elegant system called RNA silencing for getting rid of foreign RNAs whether they be of viral, retrotransposon, or transgene origin. In his Perspective, Baulcombe examines new findings (Wu-Scharf et al.) showing that in a green alga the gene responsible for RNA silencing encodes an RNA helicase (related to proteins in worms and other organisms) that is required for regulation of gene expression at the RNA level.

The author is at the Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, UK. E-mail: david.baulcombe{at}bbsrc.ac.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inducible Antisense-mediated Post-transcriptional Gene Silencing in Transgenic Pine Cells Using Green Fluorescent Protein as a Visual Marker.
W. Tang, K. Kinken, and R. J. Newton (2005)
Plant Cell Physiol. 46, 1255-1263
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Translation Start Sequences Affect the Efficiency of Silencing of Agrobacterium tumefaciens T-DNA Oncogenes.
H. Lee, J. L. Humann, J. S. Pitrak, J. T. Cuperus, T. D. Parks, C. A. Whistler, M. C. Mok, and L. W. Ream (2003)
Plant Physiology 133, 966-977
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RNA Helicase MUT-14-Dependent Gene Silencing Triggered in C. elegans by Short Antisense RNAs.
M. Tijsterman, R. F. Ketting, K. L. Okihara, T. Sijen, and R. H. A. Plasterk (2002)
Science 295, 694-697
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K+-Channel Transgenes Reduce K+ Currents in Paramecium, Probably by a Post-translational Mechanism.
K.-Y. Ling, W. J. Haynes, L. Oesterle, C. Kung, R. R. Preston, and Y. Saimi (2001)
Genetics 159, 987-995
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Post-transcriptional gene silencing in plants.
H. Vaucheret, C. Beclin, and M. Fagard (2001)
J. Cell Sci. 114, 3083-3091
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