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Science 6 October 2000:
Vol. 290. no. 5489, pp. 82 - 83
DOI: 10.1126/science.290.5489.82
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Doing Immunology on a Chip

Michael Hagmann

Using DNA microarrays to measure changes in gene expression patterns may reveal the mysteries of normal immune cells and also of diseases in which immune cells go astray, such as autoimmunity and cancer. Information gleaned by microarray analysis should also help to both diagnose disease and find new therapies. But like other chip users, immunologists are facing a looming data overload, as every single chip provides information on thousands of gene changes; distilling the few that actually matter for the biological activity under investigation will require the ability to present the data in a way the human mind can comprehend.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)