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Science 6 October 2000:
Vol. 290. no. 5489, pp. 80 - 82
DOI: 10.1126/science.290.5489.80
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Computers Aid Vaccine Design

Michael Hagmann

Immunologists are using computer algorithms to help them identify the antigen fragments that trigger immune responses and might thus lead to vaccines for diseases ranging from malaria to cancer. Such "subunit vaccines," immunologists hope, will be less dangerous than those using whole pathogens or cancer cells. But they caution that, despite the number of promising preclinical studies, the algorithms still have to prove their worth on the real-life battlefield between pathogen and host.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure of a Complex of the Human {alpha}/{beta} T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity.
J. Hennecke and D. C. Wiley (2002)
J. Exp. Med. 195, 571-581
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Mechanism of Actin-Based Motility.
D. Pantaloni, C. L. Clainche, and M.-F. Carlier (2001)
Science 292, 1502-1506
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Science. ISSN 0036-8075 (print), 1095-9203 (online)