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Science 28 July 2000:
Vol. 289. no. 5479, pp. 559 - 560
DOI: 10.1126/science.289.5479.559
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Perspectives
CELL BIOLOGY:
A Universal Bicarbonate Sensor
U. Benjamin Kaupp and Ingo Weyand
The life-span of sperm may be short but it is certainly busy. The three principal molecular events that prepare sperm for fertilization are all controlled by the intracellular nucleotide adenosine 3',5'-monophosphate (cAMP). One of these, capacitation, is also regulated by bicarbonate ions. The elusive connection between cAMP and bicarbonate ions now appears to be solved as Kaupp and Weyand explain in their Perspective. Bicarbonate ions enter sperm through the anion transporter in the sperm plasma membrane and activate the soluble form of adenylyl cyclase, the enzyme that synthesizes cAMP (Chen et al.)
The authors are at the Institut für Biologische Informationsverarbeitung, Forschungszentrum Jülich, Germany. E-mail: a.eckert{at}fz-juelich.de, i.weyand{at}fz-juelich.de
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- Involvement of Cytoplasmic Free Calcium in Boar Sperm: Head-to-Head Agglutination Induced by a Cell-Permeable Cyclic Adenosine Monophosphate Analog.
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- Identification and Functional Analysis of Splice Variants of the Germ Cell Soluble Adenylyl Cyclase.
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