MOLECULAR BIOLOGY: Targeting Intron Insertion Into DNA

doi:10.1126/science.289.5478.374

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Science 21 July 2000:
Vol. 289. no. 5478, p. 374
DOI: 10.1126/science.289.5478.374

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MOLECULAR BIOLOGY:
Targeting Intron Insertion Into DNA

Evelyn Strauss

In work reported on page 452, researchers have found a way to coax certain introns, bits of genetic debris that litter the DNA and interrupt the coding sequences of many genes, to hop into the exact sequences where the researchers want them. The method could enhance all sorts of genetic manipulations, from studying basic gene function to combating viral infections to delivering genes for gene therapy.

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In Science Magazine

REPORTS Group II Introns Designed to Insert into Therapeutically Relevant DNA Target Sites in Human Cells: Huatao Guo, Michael Karberg, Meredith Long, J. P. Jones, III, Bruce Sullenger, and Alan M. Lambowitz (21 July 2000)
Science 289 (5478), 452. [DOI: 10.1126/science.289.5478.452]
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