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Science 24 September 1999:
Vol. 285. no. 5436, pp. 2076 - 2077
DOI: 10.1126/science.285.5436.2076
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

NEUROBIOLOGY:
Enhanced: Narcolepsy Genes Wake Up the Sleep Field

Joseph S. Takahashi

Narcolepsy, a sleep disorder affecting 1 in 2000 adults, is characterized by excessive daytime sleepiness and a disruption in REM sleep (the part of our sleep cycle during which we dream). Now, two recent papers in the journal Cell identify the narcolepsy gene in dogs and in mice. In a fascinating Perspective, Takahashi explains that the newly identified gene encodes a receptor for orexin, a neuropeptide involved in feeding behavior and energy metabolism. As discussed by Takahashi, working out the different pathways of feeding and sleep and how they are intertwined will keep many researchers busy for a long time to come.

The author is in the Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, 2153 North Campus Drive, Evanston, IL 60208-3520. E-mail: j-takahashi{at}nwu.edu

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E-Letters:

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Hypocretin nomenclature
J. Gregor Sutcliffe
Science Online, 2 Mar 2000 [Full text]

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Science. ISSN 0036-8075 (print), 1095-9203 (online)