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Science 11 December 2009:
Vol. 326. no. 5959, pp. 1468 - 1469
DOI: 10.1126/science.326.5959.1468-b

News of the Week

Gene Therapy:

β-Thalassemia Treatment Succeeds, With a Caveat

Jocelyn Kaiser

Gene therapy researchers are approaching a key milestone: They appear to have controlled an inherited blood disorder called β-thalassemia that's more common than any disease treated so far with gene therapy. A young man who received new genes to repair blood cells no longer needs regular transfusions and, 2 years later, seems healthy. Describing this success last week to a U.S. review panel in Bethesda, Maryland, a researcher added a caveat: The inserted gene may have turned on growth signals, raising the potential for cancer.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)