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Science 9 October 2009:
Vol. 326. no. 5950, pp. 239 - 240
DOI: 10.1126/science.1182009
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Perspectives

Genetics:

Life After GWA Studies

Emmanouil T. Dermitzakis1 and Andrew G. Clark2

In the Hollywood movie GATACCA, an infant's genome sequence is produced in seconds and the probabilities of dozens of chronic disorders roll off the screen. Although real-world progress in technologies for DNA sequencing seems to be approaching the science fiction version of genomics, the ability to predict an individual's risk of chronic disease based on DNA sequence is lagging behind. How do we bridge this gap? Or is it time to reconsider the goal of accurately predicting individual risk?

1 Department of Genetic Medicine and Development, University of Geneva Medical School, 1 Rue Michel-Servet, Geneva 1211, Switzerland.
2 Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

E-mail: emmanouil.dermitzakis{at}unige.ch

E-mail: ac347{at}cornell.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)