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Science 12 June 2009:
Vol. 324. no. 5933, pp. 1394 - 1395
DOI: 10.1126/science.1169920
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Policy Forum

Drug Discovery:

Repurposing with a Difference

Mark S. Boguski,1,* Kenneth D. Mandl,2 Vikas P. Sukhatme3

There is widespread belief that current models of drug discovery and development need revamping and reinvention in order to make pharmaceutical research and development (R&D) more predictable, reliable, and less costly. We suggest a novel approach to this challenge that involves profound changes in the way postmarketing surveillance data are gathered and used. This approach capitalizes on recent advances in molecular medicine, human genomics, and information technology, as well as an increasingly sophisticated public eager for solutions to their unmet medical needs. Novel business models and imaginative legal and regulatory reforms will be critical to fulfill this promise and to maximize its impact.

1 Department of Pathology, Beth Israel Deaconess Medical Center and Center for Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA.
2 Children's Hospital Informatics Program at Harvard-MIT, Division of Health Sciences and Technology and Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
3 Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

* To whom correspondence should be addressed. E-mail: mark_boguski{at}hms.harvard.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antibiotics for Emerging Pathogens.
M. A. Fischbach and C. T. Walsh (2009)
Science 325, 1089-1093
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