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Science 10 April 2009:
Vol. 324. no. 5924, pp. 192 - 194
DOI: 10.1126/science.1173362
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Perspectives

CANCER:
Puzzling Patterns of Predisposition

Patrick J. Pollard and Peter J. Ratcliffe

Mutations in a gene that encodes a metabolic enzyme have been linked to certain brain tumors, but is the gene a tumor suppressor or an oncogene?

Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, UK. E-mail: pjr{at}well.ox.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)