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Science 27 June 2008:
Vol. 320. no. 5884, p. 1709
DOI: 10.1126/science.320.5884.1709a
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News of the Week

VIROLOGY:
'Biased' Viruses Suggest New Vaccine Strategy for Polio and Other Diseases

Martin Enserink

Introducing hundreds of seemingly inconsequential mutations into a poliovirus can cripple the virus enough to make it work as a live vaccine in mice, scientists report on page 1784 of this week's issue of Science. The technology might lead to safer polio vaccines and perhaps to so-called live attenuated vaccines against other diseases.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)