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Science 29 February 2008:
Vol. 319. no. 5867, pp. 1191 - 1192
DOI: 10.1126/science.1155750
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Perspectives

CELL BIOLOGY:
No ESCRTs for Exosomes

Mark Marsh1 Gerrit van Meer2

Two pathways within endosomes use specific protein complexes or membrane domains to direct cargo for degradation or secretion from cells.

1Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. E-mail: m.marsh{at}ucl.ac.uk

2Membrane Enzymology, Bijvoet Center/Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands. E-mail: g.vanmeer{at}uu.nl

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Science. ISSN 0036-8075 (print), 1095-9203 (online)