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Science 15 February 2008:
Vol. 319. no. 5865, pp. 914 - 915
DOI: 10.1126/science.1154515
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Perspectives

MEDICINE:
Sidestepping Mutational Meltdown

Eric A. Shoubridge and Timothy Wai

Mouse mitochondrial DNA with severe mutations is not passed down to later generations, but the selection process is unclear.

The authors are at the Montreal Neurological Institute and Department of Human Genetics, McGill University, Montreal, Quebec H3A 2B4, Canada. E-mail: eric{at}ericpc.mni.mcgill.ca

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Science. ISSN 0036-8075 (print), 1095-9203 (online)