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Science 11 January 2008:
Vol. 319. no. 5860, pp. 154 - 156
DOI: 10.1126/science.319.5860.154
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News Focus

CANCER IMMUNOLOGY:
Cancer's Bulwark Against Immune Attack: MDS Cells

Jean Marx

First noticed in the 1970s, myeloid-derived suppressor cells appear to play a key role in sustaining tumors; new methods of overcoming them are being tested.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer.
S. Ostrand-Rosenberg and P. Sinha (2009)
J. Immunol. 182, 4499-4506
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Potent induction of B- and T-cell immunity against human carcinoembryonic antigen-expressing tumors in human carcinoembryonic antigen transgenic mice mediated by direct lentivector injection.
S. Loisel-Meyer, T. Felizardo, J. Mariotti, M. E. Mossoba, J. E. Foley, R. Kammerer, N. Mizue, R. Keefe, J. A. McCart, W. Zimmermann, et al. (2009)
Mol. Cancer Ther. 8, 692-702
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Transforming Growth Factor {beta}: Tumor Suppressor or Promoter? Are Host Immune Cells the Answer?.
L. Yang and H. L. Moses (2008)
Cancer Res. 68, 9107-9111
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Myeloid-Derived Suppressor Cells in Cancer Cachexia Syndrome: A New Explanation for an Old Problem.
R. D. Winfield, M. J. Delano, K. Pande, P. O. Scumpia, D. LaFace, and L. L. Moldawer (2008)
JPEN J Parenter Enteral Nutr 32, 651-655
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Science. ISSN 0036-8075 (print), 1095-9203 (online)