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Science 7 December 2007:
Vol. 318. no. 5856, pp. 1565 - 1566
DOI: 10.1126/science.1152905
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Essays on Science and Society

GE PRIZE-WINNING ESSAY:
Why Old World Monkeys Are Resistant to HIV-1

Matthew Stremlau

Premature disassembly of the HIV-1 capsid is caused by the rhesus monkey protein, TRIM5alpha, and a single amino acid change in human TRIM5alpha confers similar anti-HIV-1 activity.

The author is at the U.S. Global AIDS Coordinator's Office at the State Department as a Fellow of the American Association for the Advancement of Science, Washington, DC 20522, USA. E-mail: stremlauMH{at}state.gov

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Science. ISSN 0036-8075 (print), 1095-9203 (online)