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Science 23 November 2007:
Vol. 318. no. 5854, pp. 1253 - 1254
DOI: 10.1126/science.1151656
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Perspectives

BIOCHEMISTRY:
Signaling Across the Cell Membrane

Rama Ranganathan

Structural and functional studies shed light on how G protein-coupled receptors sense external stimuli.

The author is at the Green Center for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. E-mail: rama.ranganathan{at}utsouthwestern.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of two distinct inactive conformations of the {beta}2-adrenergic receptor reconciles structural and biochemical observations.
R. O. Dror, D. H. Arlow, D. W. Borhani, M. O. Jensen, S. Piana, and D. E. Shaw (2009)
PNAS 106, 4689-4694
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Science. ISSN 0036-8075 (print), 1095-9203 (online)