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Science 16 November 2007:
Vol. 318. no. 5853, pp. 1048 - 1049
DOI: 10.1126/science.318.5853.1048
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News of the Week

AIDS RESEARCH:
Did Merck's Failed HIV Vaccine Cause Harm?

Jon Cohen

SEATTLE, WASHINGTON--AIDS researchers met here last week to explore an alarming finding: A vaccine candidate may actually have increased the risk of HIV infection in some study participants.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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H. Tanaka, H. Chiba, J. Inokoshi, A. Kuno, T. Sugai, A. Takahashi, Y. Ito, M. Tsunoda, K. Suzuki, A. Takenaka, et al. (2009)
PNAS 106, 15633-15638
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Single-Injection Vaccine Protects Nonhuman Primates against Infection with Marburg Virus and Three Species of Ebola Virus.
T. W. Geisbert, J. B. Geisbert, A. Leung, K. M. Daddario-DiCaprio, L. E. Hensley, A. Grolla, and H. Feldmann (2009)
J. Virol. 83, 7296-7304
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Comparison of Human and Rhesus Macaque T-Cell Responses Elicited by Boosting with NYVAC Encoding Human Immunodeficiency Virus Type 1 Clade C Immunogens.
P. Mooij, S. S. Balla-Jhagjhoorsingh, N. Beenhakker, P. van Haaften, I. Baak, I. G. Nieuwenhuis, S. Heidari, H. Wolf, M.-J. Frachette, K. Bieler, et al. (2009)
J. Virol. 83, 5881-5889
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Gag-Specific Cytotoxic T-Lymphocyte-Based Control of Primary Simian Immunodeficiency Virus Replication in a Vaccine Trial.
M. Kawada, T. Tsukamoto, H. Yamamoto, N. Iwamoto, K. Kurihara, A. Takeda, C. Moriya, H. Takeuchi, H. Akari, and T. Matano (2008)
J. Virol. 82, 10199-10206
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Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains.
P. Lauer, B. Hanson, E. E. Lemmens, W. Liu, W. S. Luckett, M. L. Leong, H. E. Allen, J. Skoble, K. S. Bahjat, N. E. Freitag, et al. (2008)
Infect. Immun. 76, 3742-3753
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Multifunctional T-Cell Characteristics Induced by a Polyvalent DNA Prime/Protein Boost Human Immunodeficiency Virus Type 1 Vaccine Regimen Given to Healthy Adults Are Dependent on the Route and Dose of Administration.
A. Bansal, B. Jackson, K. West, S. Wang, S. Lu, J. S. Kennedy, and P. A. Goepfert (2008)
J. Virol. 82, 6458-6469
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A DNA Vaccine Prime Followed by a Liposome-Encapsulated Protein Boost Confers Enhanced Mucosal Immune Responses and Protection.
K. Yang, B. J. Whalen, R. S. Tirabassi, L. K. Selin, T. S. Levchenko, V. P. Torchilin, E. H. Kislauskis, and D. L. Guberski (2008)
J. Immunol. 180, 6159-6167
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Vaccine Protection by Live, Attenuated Simian Immunodeficiency Virus in the Absence of High-Titer Antibody Responses and High-Frequency Cellular Immune Responses Measurable in the Periphery.
K. Mansfield, S. M. Lang, M.-C. Gauduin, H. B. Sanford, J. D. Lifson, R. P. Johnson, and R. C. Desrosiers (2008)
J. Virol. 82, 4135-4148
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The Challenge of HIV-1 Subtype Diversity.
B. S. Taylor, M. E. Sobieszczyk, F. E. McCutchan, and S. M. Hammer (2008)
N. Engl. J. Med. 358, 1590-1602
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The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?.
R.-P. Sekaly (2008)
J. Exp. Med. 205, 7-12
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