Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Johnson & Johnson

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 November 2007:
Vol. 318. no. 5853, p. 1033
DOI: 10.1126/science.318.5853.1033i
Prev | Table of Contents | Next

This Week in Science

Inflammatory responses in the nervous system are very tightly regulated. In particular, T helper 1 type T cell responses must be kept in check, and a potent negative regulator of these cells is the surface receptor TIM3, a member of the T cell immunoglobulin and mucin family. However, Anderson et al. (p. 1141) report the unexpected finding that TIM3 also promotes inflammation through expression on cells of the innate immune system--namely, dendritic cells and microglia of the brain. The opposing roles for the same immune protein when expressed on different populations of immune cells raises intriguing questions about the balance between the promotion and inhibition of tissue inflammation.




ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)