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Science 2 November 2007:
Vol. 318. no. 5851, pp. 757 - 758
DOI: 10.1126/science.1150740
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Perspectives

SYSTEMS BIOLOGY:
A Clock with a Flip Switch

Andy C. Poon and James E. Ferrell Jr.,

The heart of circadian timekeeping in cyanobacteria is a toggle switch that controls the periodic phosphorylation of a key circuit protein.

The authors are in the Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA. E-mail: james.ferrell{at}stanford.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)