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Science 5 October 2007:
Vol. 318. no. 5847, pp. 28 - 29
DOI: 10.1126/science.318.5847.28
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News of the Week

AIDS RESEARCH:
Promising AIDS Vaccine's Failure Leaves Field Reeling

Jon Cohen

The failure of a promising AIDS vaccine in a large human trial, dubbed STEP, has stunned researchers and raised concerns about the broader T-cell vaccine concept and the future of AIDS vaccine research and development.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comparison of Human and Rhesus Macaque T-Cell Responses Elicited by Boosting with NYVAC Encoding Human Immunodeficiency Virus Type 1 Clade C Immunogens.
P. Mooij, S. S. Balla-Jhagjhoorsingh, N. Beenhakker, P. van Haaften, I. Baak, I. G. Nieuwenhuis, S. Heidari, H. Wolf, M.-J. Frachette, K. Bieler, et al. (2009)
J. Virol. 83, 5881-5889
   Abstract »    Full Text »    PDF »
Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants.
M. Elinder, H. Nordstrom, M. Geitmann, M. Hamalainen, L. Vrang, B. Oberg, and U. H. Danielson (2009)
J Biomol Screen 14, 395-403
   Abstract »    PDF »
Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains.
P. Lauer, B. Hanson, E. E. Lemmens, W. Liu, W. S. Luckett, M. L. Leong, H. E. Allen, J. Skoble, K. S. Bahjat, N. E. Freitag, et al. (2008)
Infect. Immun. 76, 3742-3753
   Abstract »    Full Text »    PDF »
Multifunctional T-Cell Characteristics Induced by a Polyvalent DNA Prime/Protein Boost Human Immunodeficiency Virus Type 1 Vaccine Regimen Given to Healthy Adults Are Dependent on the Route and Dose of Administration.
A. Bansal, B. Jackson, K. West, S. Wang, S. Lu, J. S. Kennedy, and P. A. Goepfert (2008)
J. Virol. 82, 6458-6469
   Abstract »    Full Text »    PDF »
A DNA Vaccine Prime Followed by a Liposome-Encapsulated Protein Boost Confers Enhanced Mucosal Immune Responses and Protection.
K. Yang, B. J. Whalen, R. S. Tirabassi, L. K. Selin, T. S. Levchenko, V. P. Torchilin, E. H. Kislauskis, and D. L. Guberski (2008)
J. Immunol. 180, 6159-6167
   Abstract »    Full Text »    PDF »
The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?.
R.-P. Sekaly (2008)
J. Exp. Med. 205, 7-12
   Abstract »    Full Text »    PDF »


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