CELL BIOLOGY: Aneuploidy in the Balance

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Science 17 August 2007:
Vol. 317. no. 5840, pp. 904 - 905
DOI: 10.1126/science.1146857

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Prasad V. Jallepalli¹ and David Pellman²

An extra chromosome slows yeast cell proliferation, suggesting that aneuploid human cells must overcome this effect during carcinogenesis.

¹P. V. Jallepalli is at the Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. E-mail: jallepap{at}mskcc.org

²D. Pellman is at the Dana-Farber Cancer Institute, Boston, MA 02115, USA. E-mail: david_pellman{at}dfci.harvard.edu

RESEARCH ARTICLES Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast: Eduardo M. Torres, Tanya Sokolsky, Cheryl M. Tucker, Leon Y. Chan, Monica Boselli, Maitreya J. Dunham, and Angelika Amon (17 August 2007)
Science 317 (5840), 916. [DOI: 10.1126/science.1142210]
| Abstract » | Full Text » | PDF » | Supporting Online Material »

Science. ISSN 0036-8075 (print), 1095-9203 (online)

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