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Science 27 July 2007:
Vol. 317. no. 5837, pp. 461 - 462
DOI: 10.1126/science.1146585
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Perspectives

MEDICINE:
The Yin-Yang of Sirtuins

Andrew Dillin1 and Jeffery W. Kelly2

Two related proteins protect cells from age-associated neurodegenerative disease, but one needs to be activated whereas the other must be inhibited.

1A. Dillin is at the Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. E-mail: dillin{at}salk.edu

2J. W. Kelly is at the Skaggs Institute for Chemical Biology and Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. E-mail: jkelly{at}scripps.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Science. ISSN 0036-8075 (print), 1095-9203 (online)