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Science 13 July 2007:
Vol. 317. no. 5835, pp. 206 - 207
DOI: 10.1126/science.1146073
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Perspectives

BIOCHEMISTRY:
PI3K Charges Ahead

Jennifer Y. Lee, Jeffrey A. Engelman, Lewis C. Cantley

Structural information about an enzyme implicated in numerous cancers provides insights into to how certain mutations promote cancer cell growth and survival.

The authors are in the Department of Systems Biology, Harvard Medical School, and in the Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. J. A. Engelman is also at Massachusetts General Hospital Cancer Center, Boston, MA 02115, USA. E-mail: lewis_cantley{at}hms.harvard.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)