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Science 27 April 2007:
Vol. 316. no. 5824, p. 511
DOI: 10.1126/science.316.5824.511a
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This Week in Science

Figure 1 Micro-RNAs (miRNAs) are abundant small RNA species that have emerged as key regulators in many biological processes. Rodriguez et al. (p. 608; see the news story by Couzin) observed that mice deficient in miRNA-155 develop spontaneous inflammation of the lungs and have accompanying defects in antigen presentation, as well as T cell and B cell function. Exploring the same miRNA, Thai et al. (p. 604; see the news story by Couzin) observed a similar T and B cell deficiency that resulted in a suboptimal response of the germinal center, which is needed for T cell-mediated antibody production. Although both studies provide some evidence for how this miRNA mediates its effects, the next important step will be to identify the precise mechanism and critical target genes involved.

CREDIT: TOGETHER DESIGN/LONDON UK




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Science. ISSN 0036-8075 (print), 1095-9203 (online)