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Science 6 April 2007:
Vol. 316. no. 5821, pp. 60 - 61
DOI: 10.1126/science.1141630
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Perspectives

CHEMISTRY:
Roots of Biosynthetic Diversity

David W. Christianson

Terpenoid synthases generate an extraordinarily diverse set of natural products. Evolution of these enzymes from a common alpha-helical ancestor has resulted in profound changes in activity.

The author is in the Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. E-mail: chris{at}sas.upenn.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
New Role of Flavin as a General Acid-Base Catalyst with No Redox Function in Type 2 Isopentenyl-diphosphate Isomerase.
H. Unno, S. Yamashita, Y. Ikeda, S.-y. Sekiguchi, N. Yoshida, T. Yoshimura, M. Kusunoki, T. Nakayama, T. Nishino, and H. Hemmi (2009)
J. Biol. Chem. 284, 9160-9167
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Science. ISSN 0036-8075 (print), 1095-9203 (online)