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High-quality statistical analyses allow tracking of HIV evasion of the host immune response through epitope mutations and suggest refined strategies for vaccine development.
P. Klenerman is in the Nuffield Department of Clinical Medicine, Peter Medawar Building, University of Oxford, Oxford OX1 3SY, UK. A. McMichael is at the Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK. E-mail: andrew.mcmichael{at}ndm.ox.ac.uk
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Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber (16 March 2007) Science315 (5818), 1583.
[DOI: 10.1126/science.1131528] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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