BIOCHEMISTRY: A Missing Link in Membrane Protein Evolution

doi:10.1126/science.1140073

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Science 2 March 2007:
Vol. 315. no. 5816, pp. 1229 - 1231
DOI: 10.1126/science.1140073

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BIOCHEMISTRY:
A Missing Link in Membrane Protein Evolution

Bert Poolman, Eric R. Geertsma, Dirk-Jan Slotboom

Discerning the orientation of subunits of an unusual bacterial membrane protein suggests how the particular topology of other membrane proteins may have evolved.

The authors are in the Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, Netherlands. E-mail: b.poolman{at}rug.nl

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LETTERS Controversy Over EmrE Structure: Shimon Schuldiner;, Mikaela Rapp, Susanna Seppälä, Erik Granseth, Gunnar Von Heijne;, Bert Poolman, Eric Geertsma, and Dirk-Jan Slotboom (10 August 2007)
Science 317 (5839), 748d. [DOI: 10.1126/science.317.5839.748d]
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REPORTS Emulating Membrane Protein Evolution by Rational Design: Mikaela Rapp, Susanna Seppälä, Erik Granseth, and Gunnar von Heijne (2 March 2007)
Science 315 (5816), 1282. [DOI: 10.1126/science.1135406]
| Abstract » | Full Text » | PDF » | Supporting Online Material »

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