Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 16 February 2007:
Vol. 315. no. 5814, p. 909
DOI: 10.1126/science.315.5814.909g
|
|
This Week in Science
The formation of discrete representations in memory has been hypothesized to reflect neuronal pattern separation at the early stages of the hippocampal formation, but both location and mechanisms of the process have remained elusive. Leutgeb et al. (p. 961; see the Perspective by Fenton) show that the hippocampus has at least two mechanisms for pattern separation associated with different parts of the hippocampal circuit. In the dentate gyrus, signals are separated by high-fidelity decorrelation of coactivity patterns within a subset of active cells. In CA3, further separation is achieved by activation of non-overlapping neuronal subpopulations. The two mechanisms of pattern separation, associated with different parts of the circuitry, support distinct forms of ensemble representation in the hippocampus.
|
|
Science. ISSN 0036-8075 (print), 1095-9203 (online)
