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Science 26 January 2007:
Vol. 315. no. 5811, p. 433
DOI: 10.1126/science.315.5811.433q
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This Week in Science
The 20 common amino acids in proteins are represented in the genome by a triplet code of four DNA bases giving a total of 64 (43) different codons, with the majority of amino acids being encoded by more than one codon. Different synonymous codons affect RNA structure and stability and also affect protein translation rates. In bacteria, they are also known to affect protein folding. Can they have a similar effect in eukaryotes? Kimchi-Sarfaty et al. (p. 525, published online 21 December with the Perspective by Komar) look at the human multidrug resistance 1 (MDR1) gene and show that a relatively common single nucleotide polymorphism--which changes ATC for ATT (both isoleucine), in combination with two other polymorphisms--causes a change in the conformation of the protein and also underlies its altered drug and inhibitor interactions.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
