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Science 26 January 2007:
Vol. 315. no. 5811, p. 433
DOI: 10.1126/science.315.5811.433o
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In Drosophila, male germline stem cells orient the mitotic spindle to generate a daughter stem cell and a cell destined for germ cell differentiation after asymmetric cell division. Using gene mutation and ultra-structural studies, Yamashita et al. (p. 518; see the Perspective by Spradling and Zheng) now identify the mechanism by which the oriented spindle is established. The mother and daughter centrosomes are differentially oriented, with the mother centrosome anchored close to the niche-stem cell junction by microtubules, whereas the daughter centrosome migrates to the other side of the cell. This differential centrosome identity and migration may provide a mechanism for asymmetric cell division in the generation of daughter cells with different developmental fates.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)