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Science 5 January 2007:
Vol. 315. no. 5808, p. 14
DOI: 10.1126/science.315.5808.14h
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Although chromosome segregation is generally considered to be random relative to daughter cell inheritance, nonrandom segregation of mouse chromosome 7 has been reported for certain cell types. Armakolas and Klar (p. 100; see the Perspective by Sapienza) examined molecular components that participate in nonrandom chromatid segregation. Mutation of a gene encoding the microtubule motor left-right dynein (LRD), shown previously to affect left-right body-axis determination, differentially affected chromatid segregation in specific cell types.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)