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Science 24 November 2006:
Vol. 314. no. 5803, p. 1213
DOI: 10.1126/science.314.5803.1213j
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This Week in Science

Figure 1 Typhoid fever is caused by Salmonella enterica serovar Typhi, which mostly affects impoverished populations in the Southern Hemisphere. Notoriously, it can be carried asymptomatically by individuals who shed large quantities of bacteria. Roumagnac et al. (p. 1301) analyzed 105 strains from around the world and discovered a population structure best explained by neutral genetic drift in which the pre-Neolithic ancestral strain and intervening mutations still exist. Various haplotypes were probably distributed globally during acute epidemics followed by prolonged persistence in the gall bladder of asymptomatic carriers.

CREDIT: ROUMAGNAC ET AL.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)