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Science 3 November 2006:
Vol. 314. no. 5800, p. 721
DOI: 10.1126/science.314.5800.721j
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Caloric dietary restriction prolongs life span in a variety of organisms, and in mammals the resultant lowering of core body temperature has been offered as one potential explanation. Conti et al. (p. 825; see the Perspective by Saper) generated transgenic mice that overexpress mitochondrial uncoupling protein 2 in hypocretin-producing neurons within the hypothalamus, which lowers core body temperature by about 0.5°C. In the absence of caloric restriction, the median life span of these "cool mice" was about 15% greater than that of their wild-type littermates.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)