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Science 20 October 2006:
Vol. 314. no. 5798, pp. 428 - 429
DOI: 10.1126/science.1134031
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Perspectives

SIGNAL TRANSDUCTION:
Protein Synthesis and Oncogenesis Meet Again

Nahum Sonenberg and Arnim Pause

A protein degradation process targets a factor that blocks protein synthesis and inhibits tumor growth. Enhanced degradation of this protein may provide a growth advantage to cancer cells.

The authors are in the Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6. E-mail: nahum.sonenberg{at}mcgill.ca; arnim.pause{at}mcgill.ca

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential Signaling Activation by Insulin and Insulin-Like Growth Factors I and II upon Binding to Insulin Receptor Isoform A.
A. Sacco, A. Morcavallo, G. Pandini, R. Vigneri, and A. Belfiore (2009)
Endocrinology 150, 3594-3602
   Abstract »    Full Text »    PDF »
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.
E. Hirsch, C. Costa, and E. Ciraolo (2007)
J. Endocrinol. 194, 243-256
   Abstract »    Full Text »    PDF »


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