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Science 20 October 2006:
Vol. 314. no. 5798, p. 381
DOI: 10.1126/science.314.5798.381h
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Controlled protein degradation is a fundamentally important cellular regulatory mechanism. Dorrello et al. (p. 467; see the Perspective by Sonenberg and Pause) searched for binding partners of the ubiquitin ligase SCFbetaTRCP and detected programmed cell death protein 4 (PDCD4). The growth factor-stimulated protein kinase, S6K1, phosphorylated PDCD4 and promoted its ubiquitination by SCFbetaTRCP and consequent degradation. The degradation of PDCD4 relieved its inhibitory effect of on a translation initiation factor and enhanced protein synthesis. Thus, regulated destruction of PDCD4 appears to regulate cell proliferation and cell size.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)