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Science 29 September 2006:
Vol. 313. no. 5795, p. 1849
DOI: 10.1126/science.313.5795.1849i
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This Week in Science

In the mouse, the immune system can recognize a developing tumor and control its growth, but whether the same is true in humans has been controversial. To investigate the impact of the immune response on the prognosis of cancer patients, Galon et al. (p. 1960; see the news story by Couzin) analyzed tumor-infiltrating immune cells in human colorectal cancers by gene expression profiling and in situ immunohistochemistry. In three independent patient populations, the properties of the immune cells (type, density, and location) within the tumors were a better predictor of recurrence and overall patient survival than tumor histopathology. Thus, information about the immune response in individual cancer patients could help optimize treatment decisions.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)