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Science 22 September 2006:
Vol. 313. no. 5794, p. 1700
DOI: 10.1126/science.313.5794.1700j
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Figure 1 beta-amyloid plays a key role in Alzheimer's disease. There also exist marked pathological similarities between Alzheimer's disease and so-called prion diseases like Mad cow disease. Meyer-Luehmann et al. (p. 1781) now show that cerebral beta-amyloid-amyloidosis can be induced by the injection of exogenous, beta-amyloid-rich brain extract, and that cerebral amyloid induction is dependent on intrinsic properties of the injected beta-amyloid agent and the host that receives the injection. The results suggest the occurrence of polymorphic beta-amyloid species with varying biological activities, reminiscent of prion strains. The findings underscore the commonalities among diseases of protein aggregation and assembly.

CREDIT: MEYER-LUEHMANN ET AL.




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