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Science 8 September 2006:
Vol. 313. no. 5792, p. 1360
DOI: 10.1126/science.313.5792.1360h
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The ability to produce proteins modified with humanlike carbohydrates is important in therapeutics and structural studies. Hamilton et al. (p. 1441) describe the genetic engineering of the secretory pathway of the yeast Pichia pastoris to produce structurally homogeneous complex, terminally sialylated human-type N-glycans on therapeutically efficacious erythropoietin. The engineered cell lines contain a total of four gene knockouts and 14 heterologous genes, the majority of which had not been identified in nature and had to be discovered through an extensive screening effort.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)