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Science 25 August 2006:
Vol. 313. no. 5790, pp. 1058 - 1059
DOI: 10.1126/science.1132538
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Perspectives

NEUROSCIENCE:
Enhanced: ZAP and ZIP, a Story to Forget

Tim V. P. Bliss,1 Graham L. Collingridge,2 Serge Laroche3

How are memories stored and retrieved? Long-awaited evidence shows directly that the strength of synaptic connections in hippocampal neurons underlies both processes.

1T. V. P. Bliss is in the Division of Neurophysiology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. E-mail: tbliss{at}nimr.mrc.ac.uk

2G. L. Collingridge is at the MRC Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, UK. E-mail: g.l.collingridge{at}bristol.ac.uk

3S. Laroche is at Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication (NAMC), CNRS UMR 8620, Universite Paris Sud, 91405 Orsay, France. E-mail: serge.laroche{at}ibaic.u-psud.fr

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PKM{zeta} Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors.
Y. Yao, M. T. Kelly, S. Sajikumar, P. Serrano, D. Tian, P. J. Bergold, J. U. Frey, and T. C. Sacktor (2008)
J. Neurosci. 28, 7820-7827
   Abstract »    Full Text »    PDF »
Differential Effects of Long-Term Potentiation Evoked at the CA3 CA1 Synapse before, during, and after the Acquisition of Classical Eyeblink Conditioning in Behaving Mice.
N. Madronal, J. M. Delgado-Garcia, and A. Gruart (2007)
J. Neurosci. 27, 12139-12146
   Abstract »    Full Text »    PDF »
Brain Plasticity Mechanisms and Memory: A Party of Four.
E. Bruel-Jungerman, S. Davis, and S. Laroche (2007)
Neuroscientist 13, 492-505
   Abstract »    PDF »
Regulation of Protein Kinase M{zeta} Synthesis by Multiple Kinases in Long-Term Potentiation.
M. T. Kelly, J. F. Crary, and T. C. Sacktor (2007)
J. Neurosci. 27, 3439-3444
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)