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Science 25 August 2006:
Vol. 313. no. 5790, p. 1016
DOI: 10.1126/science.313.5790.1016h
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This Week in Science
The phenomenon of synaptic long-term potentiation (LTP) was discovered more than 30 years ago in the hippocampus. Although it is commonly thought that hippocampal LTP is induced by learning, there has not been a direct demonstration (see the Perspective by Bliss et al.). Whitlock et al. (p. 1093) recorded field potentials from multiple sites in hippocampal area CA1 before and after single-trial inhibitory avoidance learning. Field potentials increased on a subset of the electrodes, and these could be specifically related to the learning event. Pastalkova et al. (p. 1141) reversed hippocampal LTP in freely moving animals using a cell-permeable inhibitor of a protein kinase. Reversal was accompanied by a complete disruption of previously acquired long-term memory in a place avoidance task, even when the kinase inhibitor was infused only during the consolidation interval. This result suggests that LTP was necessary for storing spatial information.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
